Michael S. Cosgrove . Assistant Professor mscosgro@syr.edu Office: 340 Life Sciences Complex (LSC) Phone: 315-443-2964; lab 443-2972/ fax: 315-443-2012 Education: • Ph.D., Syracuse University, 1998 • Postdoc, Johns Hopkins School of Medicine, 2001-2005 • Postdoc, Cornell University, 1999-2000 Courses • BIO 700 Covalent Protein Modifications • BIO 700 Graduate Research Seminarr • BIO 575 Biochemistry I • BIO 576 Biochemistry II Interdisciplinary Programs: •Faculty member, SB3 Program

RESEARCH

Structural biochemistry of proteins involved in the epigenetic regulation of chromatin structure

Cosgrove Lab at Syracuse University: http://biology.syr.edu/cosgroveresearch.html

FUNDING:

Basil O'Connor Award, March of Dimes Foundation.

New Investigator Award. Leukemia Research Foundation. Molecular mechanisms for the assembly and regulation of the MLL-core complex”. The grant is for $100,000.

SELECTED PUBLICATIONS:

Patel, A., Dharmarajan, V., and Cosgrove, M.S. (2008). Structure of WDR5 bound to Mixed Lineage Leukemia Protein-1 peptide. Journal of Biological Chemistry doi: 10.1074/jbc.C800164200. (Accelerated Publication, Featured on the Journal Cover, In press).

Patel, A., Vought, V.E., Dharmarajan, V., and Cosgrove, M.S. (2008). A conserved arginine containing motif crucial for the assembly and enzymatic activity of the Mixed Lineage Leukemia protein-1 core complex. Journal of Biological Chemistry doi:10.1074/jbc.M806317200. (Featured on the Journal Cover, In press).

Cosgrove, M.S. (2007) Histone proteomics and the epigenetic regulation of nucleosome mobility. Expert Review of Proteomics 4, 465-478. (Invited Perspective).

Cosgrove, M.S., Bever, K., Avalos, J.L., Muhammad, S., Zhang, X., and Wolberger, C. (2006). The Structural Basis of Sirtuin Substrate Affinity. Biochemistry 45, 7511-7521.

Hyland, E.M., Cosgrove, M.S., Molina, H., Wang, D., Pandey, A., Cotter, R.J., and Boeke, J.D. (2005). Insights into the role of histone H3 and H4 core modifiable residues in Saccharomyces cerevisiae. Mol. Cell. Biol. 25, 10060-10070.

Cosgrove, M.S., and Wolberger, C. (2005). How does the histone code work? Biochemistry and Cell Biology 83, 468-476. (Featured on the cover).

Cosgrove, M.S., Boeke J.D., and Wolberger C. (2004) Regulated nucleosome mobility and the histone code. Nature Structural & Molecular Biology 11, 1037-1043.(Highlighted on the Nature Milestones Gene Expression website).