Michael S. Cosgrove . Assistant Professor Structural biochemistry of proteins involved in the epigenetic regulation of chromatin structure mscosgro@syr.edu Office: 406 Lyman Hall Phone: 315-443-2964; lab 443-2972/ fax: 315-443-2156 Education: • Ph.D., Syracuse University, 1998 • Postdoc, Johns Hopkins School of Medicine, 2001-2005 • Postdoc, Cornell University, 1999-2000 Courses • BIO 700 Covalent Protein Modifications • BIO 700 Graduate Research Seminar • BIO 576 Biochemistry II • BIO 575 Biochemistry I Interdisciplinary Programs: •Faculty member, SB3 Program

RESEARCH

Cosgrove Lab at Syracuse University: http://biology.syr.edu/cosgroveresearch.html

FUNDING:

Basil O'Connor Award, March of Dimes Foundation.

SELECTED PUBLICATIONS:

Cosgrove, M.S. (2007) Histone proteomics and the epigenetic regulation of nucleosome mobility. Expert Review of Proteomics 4, 465-478. (Invited Perspective).

Cosgrove, M.S., Bever, K., Avalos, J.L., Muhammad, S., Zhang, X., and Wolberger, C. (2006). The Structural Basis of Sirtuin Substrate Affinity. Biochemistry 45, 7511-7521.

Hyland, E.M., Cosgrove, M.S., Molina, H., Wang, D., Pandey, A., Cotter, R.J., and Boeke, J.D. (2005). Insights into the role of histone H3 and H4 core modifiable residues in Saccharomyces cerevisiae. Mol. Cell. Biol. 25, 10060-10070.

Cosgrove, M.S., and Wolberger, C. (2005). How does the histone code work? Biochemistry and Cell Biology 83, 468-476. (Featured on the cover).

Cosgrove, M.S., Boeke J.D., and Wolberger C. (2004) Regulated nucleosome mobility and the histone code. Nature Structural & Molecular Biology 11, 1037-1043.(Highlighted on the Nature Milestones Gene Expression website).

Park, J.H., Cosgrove, M.S., Youngman E., Wolberger C., and Boeke J.D. (2002) A core nucleosome surface crucial for transcriptional silencing. Nature Genetics 32, 273-9. (Recommended reading by the Faculty of 1000 website).

Cosgrove M.S., Gover S., Naylor C.E., Vanderputte-Rutten L., Adams M.J., and Levy H.R. (2000). An examination of the role of Asp-177 in the His-Asp catalytic dyad of glucose 6-phosphate dehydrogenase of Leuconostoc mesenteroides: X-ray structure and pH dependence of kinetic parameters of the D177N mutant enzyme. Biochemistry 39, 15002-15011.