Sandra Hewett







Faculty and Research


Sandra Hewett

Beverly Petterson Bishop Professor of Neuroscience; Professor of Biology
Office: 362 LSC; Lab 385 LSC
Phone: 315-443-9657 ; Lab: 315-443-2743


B.S, Providence College
Ph.D., Michigan State University

Research interests

Mechanisms underlying cell death in the central nervous system: the interplay between excitotoxicity and inflammation.

Selected Publications

Hewett JA, Hewett SJ. (2012) Induction of nitric oxide synthase-2 expression and measurement of nitric oxide production in enriched primary cortical astrocyte cultures. Methods Mol Biol. 814:251-63.

Uliasz TF, Hamby ME, Jackman NA, Hewett JA, Hewett SJ. (2012) Generation of primary astrocyte cultures devoid of contaminating microglia. Methods Mol Biol. 814:61-79.

Claycomb RJ, Hewett SJ, Hewett JA. (2012) Neuromodulatory role of endogenous interleukin-1β in acute seizures: possible contribution of cyclooxygenase-2. Neurobiol Dis. 45(1):234-42.

Sen E, Basu A, Willing LB, Uliasz TF, Myrkalo JL, Vannucci SJ, Hewett SJ, Levison SW. (2011) Pre-conditioning induces the precocious differentiation of neonatal astrocytes to enhance their neuroprotective properties. ASN Neuro. 2011 Jul 26;3(3):e00062. doi: 10.1042/AN20100029.

Claycomb RJ, Hewett SJ, Hewett JA. (2011) Prophylactic, prandial rofecoxib treatment lacks efficacy against acute PTZ-induced seizure generation and kindling acquisition. Epilepsia. 52(2):273-83.

Jackman NA, Uliasz TF, Hewett JA, Hewett SJ (2010) Regulation of System xc- Activity and Expression in Astrocytes by Interleukin-1b: Implications for Hypoxic Neuronal Injury. Glia. 2010 Jul 19. [Epub ahead of print] PMID: 20645408 [PubMed - as supplied by publisher]

Hamby ME, Hewett JA, Hewett SJ. (2010) Smad3-dependent signaling underlies the TGF-b1-mediated enhancement in astrocytic iNOS expression. Glia. 2010 Aug 15;58(11):1282-91. PMID: 20607716 [PubMed - in process]

Chi-un C, Lewerenz J, Fischer, G., Uliasz, T.F. Espey, M.G., Hummel, F. C, King, B., Schwedhelm, E., Böger, R.H., Gerloff, R. Hewett, S.J., Magnus, T., Donzelli, S. (2009) HNO exacerbates ischemic cerebral injury and oxidative neurotoxicity. Journal of Neurochemistry 110: 1766-1773.

Hamby, M.E., Hewett, J.A. and Hewett, S. J. (2008) TGF-?1 reduces the heterogeneity of astrocytic cyclooxygenase-2 and nitric oxide synthase-2 gene expression in a stimulus-independent manner. Prostaglandins and other lipid mediators 85:115-124.

Hamby, M.E., Gragnolati, A.R., Hewett, S.J. and Hewett, J.A. (2008) TGF-β1 and TNFα potentiate astrocytic nitric oxide production by recruiting distinct sub-populations of astrocytes to express NOS-2. Neurochem. Int. 52: 962-971.

Taylor. A.L.,Bonventre, J.V., Hewett, J.A., Hewett, S.J. (2008) Cytosolic phospholipase A2α inhibition prevents neuronal NMDA receptor-stimulated arachidonic acid mobilization and prostaglandin production but not subsequent cell death Journal of Neurochemistry 106: 1828-1840.

Fogal, B. Li, J., Lobner, D., McCullough, L.D. and Hewett, S.J. (2007) System xc- activity and astrocytes are necessary for IL-1?-mediated hypoxic neuronal injury. Journal of Neuroscience 27: 10094-10105.

View more publications, see Pubmed listing.