Faculty and Research


Eleanor M. Maine


Office: LSC 346
Phone: 315-443-9169
Lab: 315-443-7276
Lab website



Ph.D., Princeton University (1984)
Postdoctoral fellow, Princeton University (1984-1986)
Postdoctoral fellow, University of Wisconsin-Madison (1986-1990)

Research interests

Genetic regulation of development; cell-signaling; germline development; RNA silencing


  • Bio 305 Integrated Biology Laboratory
  • Bio 503 Developmental Biology
  • Bio 700 Animal Developmental Mechanisms

Interdisciplinary Programs

  • Structural Biology, Biochemistry, and Biophysics Program

Selected Publications

Van Wynsberghe, P. M., and E. M. Maine (2012) Epigenetic control of germline development. Advances in Experimental Medicine and Biology 757:373-403. Editor: T. Schedl. Publisher: Springer Verlag.

Fox, P.M., V.E. Vought, M. Hanazawa, M-H. Lee, E. M. Maine, and T. Schedl (2011) Cyclin E/CDK-2 regulates proliferative cell fate and cell cycle progression in the C. elegans germline.  Development 138, 2223-2234.

Maine, E.M. (2010) Meiotic silencing in Caenorhabditis elegansInternational Review of Cell and Molecular Biology 282, 91-134.

She, X., X. Xu, A. Fedotov, W.G. Kelly, and E.M. Maine (2009) Regulation of heterochromatin assembly during C. elegans meiosis by components of a small RNA-mediated pathway.  PLoS Genet 5(8): e1000624. doi:10.1371/journal.pgen.1000624

Maine, E.M. (2008) Studying gene function in Caenorhabditis elegans using RNA-mediated interference.  Briefings in Functional Genomics and Proteomics 7, 184-194.

Liu, Y., and E.M. Maine (2007) The Bro1-domain protein, EGO-2, promotes Notch signaling in Caenorhabditis elegans.  Genetics 177, 2265-2277.
*This paper was featured in the Genetics Society of America Newsletter.

Maine, E. M., J. Hauth, T. Ratliff, V.E. Vought, X. She, and W. G. Kelly (2005) EGO-1, a putative RNA-dependent RNA polymerase, is required for heterochromatin assembly on unpaired DNA during C. elegans meiosis.  Current Biology 15, 1972-1978. 
*This paper was cited by the Faculty of 1000

Smardon, A., J. M. Spoerke, S. C. Stacey, M. E. Klein, N. Mackin, and E. M. Maine (2000) EGO-1 is related to RNA-directed RNA polymerase and functions in germline development and RNA interference in C. elegans.  Current Biology 10, 169-178.
*This paper was featured in Science Editor's Choice and Current Biology Dispatch reviews.