George M. Langford . Professor of Biology Dean College of Arts & Sciences Cell Biology and Neuroscience glangfor@syr.edu Office: 364 Life Sciences Complex (LSC) Phone: 315-443-7617; lab 315-443-7617/ fax: 315-443-2012 Dean’s Office: 300 Hall of Languages Phone: 315-443-3949 Education: • Ph.D., Illinois Institute of Technology,1971 • Postdoctoral Fellow, University of Pennsylvania,1971-73

RESEARCH

Cell and Molecular Biology of the Actin Cytoskeleton in Health and Disease: Axonal Transport in Nerve Cells and Fungal Pathogenesis of Epithelial Cells.

SELECTED PUBLICATIONS:

Wöllert, T., Rollenhagen, C., Young, M.C., Sundstrom, P., Langford, G.M. (in preparation). Activation of Rho GTPase signaling pathways in human oral keratinocytes by pathogenic C. albicans.

Wöllert, T., Langford, G.M. (in preparation). Vesicle transport assay.

Wöllert, T., Langford, G.M. 2009. High resolution light microscopy of cell migration: long-term imaging and analysis. Methods Mol. Biol. In press.

Rollenhagen, C., Wöllert, T., Langford, G.M., Sundstrom, P. 2009. Stimulation of cell motility and expression of late markers of differentiation in human oral keratinocytes by Candida albicans. Cell. Microbiol. In press.

Swiatecka-Urban, A., Talebian, L., Kanno, E., Moreau-Marquis, S., Coutermarsh, B., Hansen, K., Karlson, K.H., Barnaby, R., Cheney, R.E., Langford, G.M., Fukuda, M., Stanton, B.A. 2007. Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells. J. Biol. Chem. 282: 23725-23736.

DePina, A.S., Wöllert, T., Langford, G.M. 2007. Membrane associated nonmuscle myosin II functions as a motor for actin-based vesicle transport in clam oocyte extracts. Cell Motil. Cytoskeleton 64: 739-755.

Stommel, E.W., van Hoff, R.M., Graber, D.J., Bercury, K.K., Langford, G.M., Harris, B.T. 2007. Tumor necrosis factor-alpha induces changes in mitochondrial cellular distribution in motor neurons. Neuroscience. 146: 1013-1019.

Swiatecka-Urban, A., Brown, A., Moreau-Marquis, S., Renuka, J., Coutermarsh, B., Barnaby, R., Karlson, K.H., Flotte, T.R., Fukuda, M., Langford G.M., Stanton B.A. 2005. The short apical membrane half-time of rescued
F508-cystic fibrosis transmembrane conductance regulator (CFTR) results from accelerated endocytosis of
F508-CFTR in polarized epithelial cells. J. Biol. Chem. 280: 36762-36772.

Swiatecka-Urban, A., Boyd, C., Coutermarsh, B., Karlson, K.H., Barnaby, R., Aschenbrenner, L., Langford, G.M., Hasson, T., Stanton, B.A. 2004. Myosin VI regulates endocytosis of the cystic fibrosis transmembrane conductance regulator. J. Biol. Chem. 279: 38025-38031.

DeSelm, C.J., Lu, R., Cheney, C.M., Langford, G.M. 2004. Identification of novel Myosin-v binding partners by immunoprecipitation and column chromatography. Biol. Bull. 207: 164.

Brown, J.R., Stafford, P., Langford, G.M. 2004. Short-range axonal/dendritic transport by myosin-V: A model for vesicle delivery to the synapse. J. Neurobiol. 58: 175-88.

Delacruz, J., Brown, J.R., Langford, G.M. 2003. Interactions between recombinant conventional squid kinesin and native myosin-V. Biol. Bull. 205: 188-190.

DeSelm, C.J., Brown, J.R., Lu, R., Langford, G.M. 2003. Rab-GDI inhibits myosin V-dependent vesicle transport in squid giant axon. Biol. Bull. 205: 190-191.

Wöllert, T., DePina, A.S., DeSelm, C.J., Langford, G.M. 2003. Rho-kinase is required for myosin-II-mediated vesicle transport during M-phase in extracts of clam oocytes. Biol. Bull. 205: 195-197.

Langford, G.M. 2002. Myosin-V, a versatile motor for short-range vesicle transport. Traffic. 3: 859-865.