Melissa Pepling . Associate Professor Regulation of mouse oocyte development; Hormone signaling in oocyte differentiation mepeplin@syr.edu Office: 348 Life Sciences Complex (LSC) Phone: 315-443-4541 / fax: 315-443-2012 Education: • Ph.D., State University of New York at Stonybrook, 1995 • Postdoc, Carnegie Institution of Washington, Dept. of Embryology, 1995-02 • Postdoc, State University of New York at Stonybrook, 1995 Courses: • BIO 425: Cell and Developmental Biology Laboratory • BIO 503: Developmental Biology • BIO 610: Graduate Research Laboratory in Biology Interdisciplinary Programs: •Faculty member, SB3 Program

RESEARCH

Pepling Lab at Syracuse University: http://biology.syr.edu/peplingresearch.html

Funding: National Science Foundation (IOB-0613895) Regulation of Oocyte Development, 2006-2009

SELECTED PUBLICATIONS:

Medico, L., Patterson, N.L., Gephardt, G.W., Sundman, E., Wilson, K.W. and Pepling, M.E. (in preparation). Neonatal Oocyte Development and Sensitivity to Estradiol Treatment in Several Different Mouse Strains.

Chen, Y., Breen, K., Raymore, J. and Pepling, M.E. (in preparation). Estrogen Can Signal Through Both ERalpha and ERbeta to Regulate Oocyte Cyst Breakdown and Primordial Follicle Assembly in the Neonatal Mouse Ovary.

Chen, Y., Jefferson, W., Newbold, R., Padilla-Banks, E. and Pepling, M.E. (2007). Estradiol, Progesterone and Genistein Inhibit Oocyte Nest Breakdown and Primordial Follicle Assembly in the Neonatal Mouse Ovary in vitro and in vivo. Endocrinology, 148, 3580-3590.

Greenfeld, C.R., Pepling, M.E., Babus, J.K., Furth, P.A. and Flaws, J.A. (2007). BAX is Involved in Regulating Follicular Endowment in Mice. Reproduction, in press.

Pepling, M.E., Wilhelm, J.E., O'Hara, A.L., Gephardt, G.W. and Spradling, A.C. (2007) Mouse Oocytes within Germ Cell Cysts and Primordial Follicles Contain a Balbiani Body. PNAS, 104:187-192.

Greenfeld, C.R. , Roby, K., Pepling, M.E., Babus, J.K., Terranova, P.F. and Flaws, J.A. (2007) Tumor Necrosis Factor Receptor Type 2 is an Important Mediator of TNF alpha Function in the Mouse Ovary.  Biology of Reproduction, 76, 224-237.

Pepling, M.E. (2006) From Primordial Germ Cell to Primordial Follicle: Mammalian Female Germ Cell Development. Genesis 44, 622-632.

Jefferson, W., Newbold, R., Padilla-Banks, E. and Pepling, M.E. (2006) Neonatal genistein treatment alters ovarian differentiation in the mouse: inhibition of oocyte nest breakdown and increased oocyte survival. Biology of Reproduction. 74:161-168.

Murphy K., Carvajal, L., Medico, L. and Pepling, M.E. (2005) Expression of Stat3 in germ cells of developing and adult mouse ovaries and testes. Gene Expression Patterns 5, 475-482.

Pepling, M.E. and Spradling, A.C. (2001). The mouse ovary contains germ cell cysts undergo programmed breakdown to form follicles. This article was published in Dev. Biol. 234, 339-351 and is posted with permission from Elsevier. Single copies of the linked article can be downloaded and printed only for the reader's personal reasearch and study. http://www.sciencedirect.com/science/journal/00121606.

Pepling, M.E., de Cuevas, M. and Spradling, A.C. (1999). Germline cysts: A conserved phase of germ cell development. This article was published in Trends Cell Biol. 9, 257-262 and is posted with permission from Elsevier. Single copies of the linked article can be downloaded and printed only for the reader's personal reasearch and study. http://www.sciencedirect.com/science/journal/09628924.

Pepling, M.E. and Spradling, A.C. (1998). Female mouse germ cells form synchronously dividing cysts. Development 125, 3323-332. [Click here for PDF].